EXHIBIT 10.1 SECOND AMENDMENT TO THE LIFEPOINT HOSPITALS, INC. EMPLOYEE STOCK PURCHASE PLAN THIS AMENDMENT is made to the LifePoint Hospitals, Inc. Employee StockPurchase Plan (the “Plan”) by LifePoint Hospitals, Inc. (the “Company”) on this15th day of December, 2005. RECITALS: WHEREAS, the Company established the Plan effective January 1, 2002 toprovide eligible employees an option to purchase the common stock of theCompany, and amended the Plan effective May 21, 2003; WHEREAS, the Plan may be amended at any time by action of the board ofdirectors of the Company; and WHEREAS, the board of directors of the Company has authorized theamendment of the Plan to modify the exercise price of shares of stock that areavailable under the Plan to reflect a discount of 5% from the market value ofsuch shares at the end of each Plan year; NOW, THEREFORE, the Plan is hereby amended as provided below, effectiveJanuary 1, 2006: SECTION 3.1(a) OF THE PLAN IS RESTATED AS FOLLOWS: (a) The exercise price of each Option shall be 95% of Fair Market Value of each share of Stock that is subject to the Option, based on the Stock’s Fair Market Value that is determined on the Exercise Date. IN WITNESS WHEREOF, the undersigned officer of the Company has executedthis Amendment on the date first written above. LIFEPOINT HOSPITALS, INC. By: William F. Carpenter III ———————— Its: Executive Vice President & Secretary ———————————— 1